The Notch Gene Accelerates Colon Carcinogenesis
Tuesday, March 24, 2009 - 10:35
in Health & Medicine
Scientists recently discovered how the Notch gene is involved in the pathogenic process leading to colon cancer. The Notch and Wnt signaling pathways play an important role in normal gut development and homeostasis. In mice, abnormal activation of these two signaling pathways increases the number of benign tumors—adenomas in the intestine by a factor of over twenty compared with activation of the Wnt pathway alone.