Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
Saturday, June 20, 2009 - 09:14
in Biology & Nature
Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds phosphates to a variety of protein substrates to modify their functions. CaMKII alpha is enriched in the hippocampus, the memory center of the brain, and is believed to be an essential mediator of activity-dependent synaptic plasticity and memory functions.