Cutting to the Core of How 3D Structure Shapes Gene Activity
Monday, July 14, 2025 - 07:21
in Biology & Nature
In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be helpful for learners to begin with the linear presentation of how stretches of DNA form genes, this oversimplification undersells the significance of the genome's 3D structure. Problems with this 3D structure are associated with many diseases including developmental disorders and cancer. Scientists at Sanford Burnham Prebys and colleagues in Hong Kong published findings June 27, 2025, in Genome Biology demonstrating a new approach for better understanding the human genome's 3D structure and its influence.