XactMice: 'Humanized' Mice Mean Better Cancer Immunotherapy Testing

Sunday, April 26, 2015 - 12:40 in Health & Medicine

Human tumors grown in mouse models have long been used to test promising anti-cancer therapies. However, when a human tumor is transplanted into a mouse, the mouse immune system must be knocked down so that it doesn't attack the foreign tumor tissue, thus allowing the tumor to grow. A University of Colorado Cancer Center study describes a new model, XactMice, in which human blood stem cells are used to grow a "humanized" mouse immune system prior to tumor transplantation. read more

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