How Does Prostate Cancer Happen?

Although prostate cancer will affect over 23,000 U.S. men next year, the individual genes that initiate prostate cancer formation are poorly understood, but finding an enzyme that regulates this process could provide excellent new prevention approaches for the malignancy. Sirtuin enzymes have been implicated in neurodegeneration, obesity, heart disease, and cancer and a new paper in The American Journal of Pathology finds that the loss of SIRT1 drives the formation of early prostate cancer (prostatic intraepithelial neoplasia) in mouse models of the disease.  read more

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