Specialized Induced Pluripotent Stem Cells Reduce Rejection Risk

The clinical promise of stem cells has been dampened by concerns that the immune system will reject the transplanted cells before they could render any long-term benefit. Previous research in mice has suggested that even adult stem cells produced from a subject's own tissue, induced pluripotent stem (iPS) cells, can trigger an immune attack. Now researchers at the Stanford University School of Medicine have found that differentiating iPS cells in the laboratory to become more-specialized progeny cells before transplantation into mice allows them to be tolerated by the body's immune system. read more

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