New Molecules Doom Proteins With Kiss Of Death
Thursday, March 6, 2014 - 02:50
in Biology & Nature
ITHACA, N.Y. – Like mobsters following strict orders, newly engineered molecules called "ubiquibodies" can mark specific proteins inside a cell for destruction – a molecular kiss of death that is paving the way for new drug therapies and powerful research tools. Led by professor Matthew DeLisa, chemical engineers at Cornell University have developed a new type of antibody, called a "ubiquibody," which is an antibody fragment they have inserted into the natural process known as the ubiquitin-proteasome pathway (UPP). Their work appears in the March 16 issue of the Journal of Biological Chemistry and is highlighted in an analysis piece in the publication SciBX. read more