A molecular on/off switch for CRISPR
Wednesday, March 29, 2017 - 08:32
in Biology & Nature
Scientists now reveal how viruses disable bacterial immune systems. For many bacteria, one line of defense against viral infection is a sophisticated RNA-guided "immune system" called CRISPR-Cas. At the center of this system is a surveillance complex that recognizes viral DNA and triggers its destruction. However, viruses can strike back and disable this surveillance complex using "anti-CRISPR" proteins, though no one has figured out exactly how these anti-CRISPRs work -- until now.