Live cell imaging reveals distinct alterations of subcellular glutathione potentials
Sunday, April 20, 2014 - 12:31
in Biology & Nature
Glutathione is the most abundant cellular redox buffer that both protects cells from oxidative damage and mediates cellular signaling. Perturbation of glutathione balance has been associated with tumorigenesis; however, due to analytical limitations, the underlying mechanisms behind this relationship are poorly understood. Utilizing a recently developed genetically encoded redox-sensitive probe has revealed differentially regulated redox environments within cellular compartments, and evidence of the contributory role of the p53 protein in supporting cytosolic redox poise.