Technique Enables Efficient Gene Splicing In Human Embryonic Stem Cells

A novel technique allows for precise, efficient gene editing into the genomes of human embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells. For years, scientists have easily swapped genes in and out of mouse ESC or iPS cell genomes, but have had a notoriously difficult time disrupting or inserting genes into their human equivalents. This hurdle has hampered efforts to create specific cell types for modeling genetic diseases, like Parkinson's.

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