Detailed Studies Reveal How Key Cancer-Fighting Protein Is Held in Check
Thursday, May 15, 2014 - 13:20
in Biology & Nature
t. Jude Children's Research Hospital scientists have mapped the structural details of how p53 attaches to its regulatory protein, called BCL-xL, in the cell. The protein p53 is a key activator of the cell's protective machinery against genetic damage, such as the mutations that drive cancer cells' explosive growth.