Handle with care: Telomeres resemble DNA fragile sites

Thursday, July 9, 2009 - 16:28 in Biology & Nature

Although telomeres are fragile, they don’t have to be handled with care. Researchers at Rockefeller University now show that what keeps our fragile telomeres from falling apart is a protein known as TRF1 that ensures the smooth progression of DNA replication to the end of a chromosome. The work not only shows how telomeres help chromosomes protect their vulnerable ends but also reveals how the genome is made more stable by them.

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