GlaxoSmithKline Gene Discovery In Poppies Paves Way For Better Painkillers

Monday, June 29, 2015 - 20:30 in Biology & Nature

A long sought after gene that is a critical gateway step in the synthesis of the morphinan class of alkaloids, which include the painkiller drugs morphine and codeine, has been discovered. The gene, called STORR, is only found in poppy species that produce morphinans. The STORR gene evolved when two other genes encoding oxidase and reductase enzymes came together millions of years ago. The resulting gene fusion plays a key role in production of morphine. The researchers hope this will enable the breeding of bespoke poppy varieties, including those that produce the anti-cancer compound noscapine. Discovery of the STORR gene completes the set of genes needed for genetic engineering of morphine production in microbes such as yeast. read more

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