FGFR1 Gene Is The Conductor In The 'Symphony Of Biology'

Friday, May 8, 2015 - 13:40 in Biology & Nature

One of developmental biology's biggest mysteries is ontogeny and the signals that transform masses of undifferentiated cells into tremendously complex organisms. A new paper suggests that it all begins with a single "master" growth factor receptor,  nuclear Fibroblast Growth Factor Receptor 1 (nFGFR1), that regulates the entire genome.  The research using mouse embryonic stem cells hopes to challenge the supposition that specific types of growth factors only functioned at a cell's surface and that growth factors function from within the nucleus. read more

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