Fatty Acid Synthesis Linked To Sepsis Inflammation
Thursday, January 15, 2015 - 17:30
in Health & Medicine
Sepsis is a leading cause of death for patients in intensive care units. The excessive systemic inflammation in individuals with sepsis damages organs and can lead to death. Therapeutic options for sepsis are limited and the factors that promote this excessive response to infection are poorly understood. A new study in the Journal of Clinical Investigation identifies a metabolic pathway that underlies sepsis inflammation. Augustine Choi and colleagues at Weill Cornell Medical College found that a mitochondrial uncoupling protein, UCP2, is elevated in patients with sepsis. In mouse model of sepsis, lack of this protein improved survival. read more