Golgi Apparatus In Cells Implicated In Alzheimer's Progression

Alzheimer's disease progresses inside the brain as deposits of the toxic protein amyloid-beta (Aβ),overwhelm neurons. A side effect of accumulating Aβ in neurons is the fragmentation of the Golgi apparatus, the part of the cell involved in packaging and sorting protein cargo including the precursor of Aβ. Or it may be the other way around and loss of Golgi function is a driving force behind Alzheimer's. Yanzhuang Wang, Gunjan Joshi, and colleagues at the University of Michigan, Ann Arbor, set out to uncover the mechanism damaging the Golgi using a transgenic mouse and tissue culture models of  Alzheimer's disease to look at what was going on.  read more

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