ABC Transporter Complex: How Cells Defend Themselves Against Antibiotics

The structure of an asymmetrical ABC transporter complex has been determined with the aid of a high-resolution cryo-electron microscope. ABC transporters cause bacteria and other pathogens to become resistant to antibiotics. They can also help cancer cells to defend themselves against cytostatic agents and thus determine whether chemotherapy will succeed.    "ABC transporters causes diseases such as cystic fibrosis, while on the other hand they are responsible for the immune system recognising infected cells or cancer cells," explains Professor Robert Tampé from the Institute for Biochemistry at the Goethe University.  read more

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