Disabling AdPLA Enzyme Lets You Eat Anything And Never Get Obese, If ...

If you're a mouse and you like fatty foods, we have good news for you.   Researchers at the University of California, Berkeley have identified a new enzyme that helps control the breakdown of fat and the mice that have had this enzyme disabled remained lean despite eating a high-fat diet and losing a hormone that suppresses appetite. The enzyme in the spotlight, adipose-specific phospholipase A2 (AdPLA), is found in abundance only in fat tissue. AdPLA sets off a chain of events that increases levels of a signaling molecule called prostaglandin E2 (PGE2), which suppresses the breakdown of fat. Mice that have no AdPLA have lower PGE2 levels and a higher rate of fat metabolism. read more

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