Est3 Protein Interaction With Telomeres May Provide Some Answers About Aging

It may take just one or two proteins to polish off a simple cellular task, but life-or-death matters, such as caring for the ends of chromosomes known as telomeres, require interacting crews of proteins, all with a common goal but each with a specialized task. Researchers at the Salk Institute for Biological Studies led by Vicki Lundblad, Ph.D., a Professor in the Molecular and Cell Biology Laboratory, have discovered that a protein that helps elongate chromosome ends—and hence saves cells from premature growth arrest—likely recognizes where to report to work through a common fold. Those findings are reported in the online edition of Nature Structure and Molecular Biology. Read More...

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