When Good Germs Go Bad: "Friendly" Gut Bacteria Can Trigger Rheumatoid Arthritis in Mice
Gut microbes deserve a lot of credit: They not only help digest our food, produce some nutrients, detoxify harmful substances, and protect us from pathogens--they are also important for the development of the immune system. Disturbances in the gut microbiota have been linked to allergies as well as disorders of the digestive and immune systems . Although intestinal organisms' impact on the digestive system's functioning is generally accepted, how they influence pathologies elsewhere in the body has remained a mystery.New research has begun to address this enigma. Diane Mathis, professor of pathology at Harvard Medical School , and her colleagues have found that one species of naturally occurring gut bacteria can set off arthritis in mice, in part by manipulating cells of the immune system. Their study appears in the June 25 issue of the journal Immunity . [More] ...