Comment on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport"
Thursday, July 20, 2017 - 13:02
in Biology & Nature
O’Brien et al. (Research Article, 24 February 2017, eaag1789) proposed a novel mechanism of primase function based on redox activity of the iron-sulfur cluster buried inside the C-terminal domain of the large primase subunit (p58C). Serious problems in the experimental design and data interpretation raise concerns about the validity of the conclusions.