Missing component of innate immune signaling identified
Wednesday, May 13, 2020 - 12:20
in Biology & Nature
Scientists have identified a new key element of the multi-component machinery responsible for sorting out the nature and severity of the pathogen challenge. The new protein, named TASL, is indispensable for the signaling of so-called Toll-like receptors (TLR) in the endosomes leading to activation of the gene-activator IRF5 in certain immune cells.