Factors behind embryonic stem cell state
Wednesday, April 17, 2019 - 16:21
in Biology & Nature
An international collaboration has found for the first time that two new epigenetic regulators, TAF5L and TAF6L, maintain self-renewal of embryonic stem cells. The scientists also found that these proteins activate c-Myc (a well-known cancer gene), and its regulatory network. This is the first time scientists have been able to show what these regulators do and how they control gene expression.