Structure of the molecular machine that links carbohydrate and lipid metabolism
Wednesday, April 3, 2019 - 13:20
in Biology & Nature
A research team has unraveled the three-dimensional structure and molecular mechanism of ATP citrate lyase (ACLY). This is a central metabolic enzyme -- a protein that accelerates chemical reactions -- important for the production of fatty acids and cholesterol in the human liver. The reported findings could help targeting ACLY in cancer and metabolic diseases such as atherosclerosis.