Structure of the molecular machine that links carbohydrate and lipid metabolism

Wednesday, April 3, 2019 - 13:20 in Biology & Nature

A research team has unraveled the three-dimensional structure and molecular mechanism of ATP citrate lyase (ACLY). This is a central metabolic enzyme -- a protein that accelerates chemical reactions -- important for the production of fatty acids and cholesterol in the human liver. The reported findings could help targeting ACLY in cancer and metabolic diseases such as atherosclerosis.

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