Rabies viruses reveal wiring in transparent brains

Thursday, January 19, 2017 - 15:01 in Biology & Nature

Scientists have harnessed rabies viruses for assessing the connectivity of nerve cell transplants: coupled with a green fluorescent protein, the viruses show where replacement cells engrafted into mouse brains have connected to the host neural network. A clearing procedure which turns the brain into a 'glass-like state' and light sheet fluorescence microscopy are used to visualize host-graft connections in a whole-brain preparation.

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