Infection with multiple HIV-1 variants leads to poorer clinical outcomes
Monday, August 31, 2015 - 15:00
in Health & Medicine
HIV-1 infection with multiple founder variants points to poorer clinical outcomes than infection with a single variant, according to research. In the study, researchers analyzed large sample sets from two important HIV vaccine efficacy trials -- the Step HIV vaccine clinical trial (HVTN 502) and RV144, the landmark vaccine clinical trial conducted in Thailand -- to evaluate whether genetic characteristics of the founder viral populations could influence markers of clinical outcomes.