Protein 'brake' in metabolic reprogramming restrains senescent cells from becoming cancerous

Thursday, April 30, 2015 - 13:31 in Biology & Nature

In recent years, research has shown that cancerous cells have a different metabolism -- essential chemical and nutritional changes needed for supporting the unlimited growth observed in cancer-- than normal cells. Now, scientists have identified a way that cells can reprogram their metabolism to overcome a tumor-suppressing mechanism known as senescence, solidifying the notion that altered metabolism is a hallmark of cancer progression.

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