HIV vaccines should avoid viral target cells, primate model study suggests
Friday, January 2, 2015 - 19:00
in Health & Medicine
Vaccines designed to protect against HIV have backfired in clinical trials. Non-human primate model studies suggest an explanation: vaccination may increase the number of immune cells that serve as viral targets. In a nonhuman primate model of HIV transmission, higher levels of viral target cells in gateway mucosal tissues were associated with an increased risk of infection.