HIV vaccines should avoid viral target cells, primate model study suggests

Friday, January 2, 2015 - 19:00 in Health & Medicine

Vaccines designed to protect against HIV have backfired in clinical trials. Non-human primate model studies suggest an explanation: vaccination may increase the number of immune cells that serve as viral targets. In a nonhuman primate model of HIV transmission, higher levels of viral target cells in gateway mucosal tissues were associated with an increased risk of infection.

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