New view of mouse genome finds many similarities, striking differences with human genome

Looking across the genomes of humans and mice, scientists have found that, in general, the systems that are used to control gene activity in both species have many similarities, along with crucial differences. The results may offer insights into gene regulation and other systems important to mammalian biology, and provide new information to determine when the mouse is an appropriate model to study human biology and disease. They may also help explain its limitations.

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