Breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics
Friday, October 31, 2014 - 04:03
in Health & Medicine
Bacteria in the GI tract fulfill many vital functions and are critical for digestion. Yet, these same bacteria can induce strong inflammatory responses by the immune system if they penetrate the gut and enter the bloodstream. Prior research has established the involvement of inflammatory processes in the development of psychiatric disorders, including major depression and alcohol dependence, but the origins of such inflammation have remained unclear. Now, researchers have found that inflammatory pathways are stimulated in alcohol-dependent patients by bacteria that escape the gut barrier, which correlated with alcohol craving.