A refined approach to proteins at low resolution

Crystals of membrane proteins and protein complexes often diffract to low resolution owing to their intrinsic molecular flexibility, heterogeneity or the mosaic spread of micro-domains. At low resolution, the building and refinement of atomic models is a more challenging task. The deformable elastic network refinement method developed previously has been instrumental in the determination of several structures at low resolution. Now, DEN refinement has been reviewed.

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