Potential Alzheimer's drug prevents abnormal blood clots in brain

The brains of Alzheimer's mice treated with the compound RU-505 showed less inflammation and improved blood flow than those of untreated mice. The treated mice also performed better on memory tests, researchers report. For more than a decade, potential Alzheimer's drugs have targeted amyloid-², but, in clinical trials, they have either failed to slow the progression of the disease or caused serious side effects. However, by targeting the protein's ability to bind to a clotting agent in blood, the work in one lab offers a promising new strategy.

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