Mutant enzyme RECQ4 connected to cancer's 'Warburg effect'

Sunday, April 20, 2014 - 12:31 in Biology & Nature

A cancer-prone mutation of the gene RECQ4 causes its corresponding enzyme, RECQ4, to accumulate in the mitochondria. This can cause mitochondrial dysfunction, possibly explaining cancer's "Warburg effect" of preferring lactic acid fermentation over aerobic respiration to generate energy. While this study provides important clues to solving the Warburg effect puzzle, the senior author said further studies are needed on RECQ4 and p32 to better explain cancer's biological processes.

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