Engineered T cells kill tumors but spare normal tissue in an animal model

Sunday, April 7, 2013 - 20:00 in Health & Medicine

Researchers devised a next gen cancer immune approach in which the activation signal for T cells is physically dissociated from a second costimulatory signal for immune cells. The two CARs carry different antigen specificity -- mesothelin and a-folate receptor. Mesothelin is primarily associated with mesothelioma and ovarian cancer, and a-folate receptor with ovarian cancer.

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