Altered brain activity responsible for cognitive symptoms of schizophrenia

Cognitive problems with memory and behavior experienced by individuals with schizophrenia are linked with changes in brain activity; however, it is difficult to test whether these changes are the underlying cause or consequence of these symptoms. By altering the brain activity in mice to mimic the activity seen in patients with schizophrenia, researchers reporting in the journal Neuron reveal that these changes in regional brain activity cause similar cognitive problems in otherwise normal mice.

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