Infection warning system in cells contains targets for antiviral and vaccine strategies

Scientists seeking to help the body better defend itself against hepatitis C, West Nile, and other serious virus infections are studying pattern recognition molecules inside living cells, called RIG-I-like receptors. When these receptors detect virus invasions, they alert the immune system to fight infection. Scientists have discovered ways certain proteins interact with RIG-I receptors to more efficiently emit signals in response to viral threats and to recruit killer T-cells. Therapeutics might be designed to mimic these actions.

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