HIV vaccine impacts the genetic makeup of the virus

Tuesday, March 1, 2011 - 15:30 in Health & Medicine

An AIDS vaccine tested in people, but found to be ineffective, influenced the genetic makeup of the virus that slipped past. This is the first evidence that vaccine-induced cellular immune responses against HIV-1 infection exert selective pressure on the virus. The findings suggest new strategies for developing HIV vaccines that put selective pressure in a controlled manner that debilitates the virus and that avoids selecting for strains that can escape immune defenses.

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