Earliest brain changes linked to Alzheimer's genetic risk point to possible prevention therapies

Sunday, December 5, 2010 - 23:30 in Health & Medicine

What are the earliest brain changes associated with the risk of developing Alzheimer's disease? A new study finds reduced activity of an energy-generating enzyme in deceased young adult brain donors who carry a common genetic risk factor for Alzheimer's disease -- before the protein changes or microscopic abnormalities commonly associated with the disease and almost five decades before the age at which they might have developed memory and thinking problems.

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