New insights into the development of epithelial cells

Scientists have gained new insights into the development of epithelial cells and their molecular repertoire. Researchers have identified a transcription factor (grainyhead-like 2, Grhl2), which regulates the composition of the molecular "bridges" that link adjacent epithelial cells. They demonstrate that Grhl2, via DNA-binding, directly regulates the expression of two such cell junctional molecules, E-cadherin and claudin 4.

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