Spying on a cellular director in the cutting room

Sunday, March 21, 2010 - 23:35 in Physics & Chemistry

Like a film director cutting out extraneous footage to create a blockbuster, the cellular machine called the spliceosome snips out unwanted stretches of genetic material and joins the remaining pieces to fashion a template for protein production. But more than box office revenues are at stake: if the spliceosome makes a careless cut, disease likely results. Researchers have now managed to spy on the splicing process in single molecules.

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