Unraveling kidney cancer: Mutations in the genome regulation machinery identified in clear cell renal cell carcinoma

Scientists have searched for mutations in more than 100 kidney cancer samples, the largest number of samples from a single tumor type to be sequenced to date. They looked for mutations in 3,544 genes to investigate the complexity within this cancer type, which is typically associated with mutations in a gene called VHL. Despite this prevalent genetic signature, the team revealed substantial genetic heterogeneity, suggesting that a complex machinery contributes to the development of cancer.

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