Researchers Prolong Half-life Of Biopharmaceutical Proteins: Biotech Innovation Could Extend Dosing Intervals, Simplify Production

To prolong the "half-life" of biopharmaceuticals such as interferon, biochemists in Germany are combining these small proteins with a molecular "balloon" that swells in the presence of water -- keeping them from being quickly filtered from the blood. The "balloon" itself consists of a biological polymer and can be produced together with the pharmaceutical protein by bacteria. In animal trials, this technology has prolonged interferon's half-life by a factor of 60.

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