Protein Modifier SUMO Helps Set Apart Females And Males

One way in which men and women differ is in their expression of liver proteins that control energy generation and lipid and steroid hormone production and turnover. Researchers have identified a new mechanism -- involving a process known as sumoylation -- underlying this differential expression of proteins in male and female mice. They also suggest drugs that may prevent estrogen-induced intrahepatic cholestasis, the most common liver disease during pregnancy.

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