Upside-down World: DNA Protecting Protein Helps Cancer Drug To Kill Cells

Some DNA repair enzymes can become double-edged swords -- If they work too slowly, they can block necessary cell maintenance and contribute to cell death. This could explain the success of the cancer drug 5-Fluorouracil (5FU) and help clinicians to predict patient's response to chemotherapy. The work reports that 5FU keeps the DNA-repair enzyme TDG too busy to perform properly in cancer cells, thereby promoting tumor death.

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