What Comes First, Misfolded Proteins Or Alzheimer's? Structural Polymorphism Of 441-residue Tau At Single Residue Resolution

Worldwide almost 30 million suffer from Alzheimer's disease. The brains of people with Alzheimer's contain two types of misfolded proteins -- amyloid plaques and tangles of the protein Tau. Whether these protein abnormalities are a cause of Alzheimer's or a consequence of the disease are unclear. A new paper in PLoS Biology investigates the structure of Tau to better understand its role in healthy cells and in the pathology of Alzheimer's.

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