Muscular Dystrophy And Exercise-induced Muscle Fatigue Have More In Common Than You Might Think

Duchenne muscular dystrophy (DMD), which is a severe disorder characterized by rapid progression of muscle weakness that ultimately leads to death, is caused by genetic mutations that result in the absence of the protein dystrophin. Loss of localization of the muscle-related molecule nNOS at the muscle cell membrane (which is known as the sarcolemma) is also observed in DMD and has been linked to muscle damage. What determines the localization of nNOS in muscle cells is not well understood.

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