BRAF Mutations In Colorectal Cancer Cause Resistance To Anti-EGFR Therapy, Study Finds

Tuesday, October 28, 2008 - 10:08 in Health & Medicine

European researchers have found that metastatic colorectal cancer patients with a mutation in the BRAF gene do not respond to anti-EGFR therapy with cetuximab and panitumumab. The finding could help doctors better identify which patients are likely to benefit from such treatment, which is commonly used as last-effort therapy but only works in a fraction of patients.

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