Gene Mutation Improves Leukemia Drug's Effect, Study Shows

Gene mutations that make cells cancerous can sometimes also make them more sensitive to chemotherapy. People with acute myeloid leukemia whose leukemic cells have mutations in the RAS gene are more likely to be cured when treated after remission with high doses of the drug cytarabine. It also suggests that testing for RAS mutations might help doctors identify which AML patients should receive high-dose cytarabine as their post-remission therapy. The findings could change how doctors manage these patients.

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