When cells find themselves in a tight spot, the cell cycle regulator p21 halts the cell cycle, buying cells time to repair the damage, or if all else fails, to initiate programmed cell death. In contrast to other stress-induced genes, which dispense with the regular transcriptional entourage, p21Cip1 still requires SKIP, a transcription elongation factor that also helps with the editing of transcripts, to be expressed, found researchers at the Salk Institute for Biological Studies...
- ‘SKIP’-ing splicing forces tumor cells to undergo programmed cell deathFri, 1 Apr 2011, 13:05:10 EDT
- The unfolding 'SAGA' of transcriptional co-activatorsThu, 14 Jul 2011, 22:35:26 EDT
- CSHL scientists discover new way in which ubiquitin modifies transcriptional machineryThu, 18 Dec 2008, 14:08:43 EST
- UM scientists demonstrate role of RNA polymerase in gene transcriptionThu, 15 Jul 2010, 12:18:39 EDT
- Getting more from whole-transcript microarraysThu, 21 May 2009, 20:30:37 EDT