Parkinson's disease may be caused by microtubule, rather than mitochondrial complex I, dysfunction
Tuesday, March 8, 2011 - 10:10
in Biology & Nature
Patients with Parkinson's disease (PD) suffer a specific loss of dopaminergic neurones from the midbrain region that controls motor function. The exact mechanism of this selective neurodegeneration is unclear, though many lines of evidence point to dysfunctional mitochondrial complex I as one root cause of the disease. Yet new research now suggests that defective regulation of microtubules may be responsible for at least some cases of PD. The study appears in the March 7 issue of The Journal of Cell Biology (www.jcb.org)...